Python Job: Research Associate, Investigative and Immuno Safet

In collaboration with the Proteomics 360 laboratory and the BioAnalytics and BioMarker chapters, we are seeking a Biochemist laboratory expert with a strong background in proteomics research using mass spectrometry. As part of the Immunosafety team, you will be actively involved in the generation and measurement of samples for the MHC-associated peptide proteomics (MAPPs) assay for assessing the immunogenicity risk of biotherapeutics candidates. The successful candidate will also work on sample preparation from various cell models (mammalian tissue culture, protein extraction, protein assays, etc.) and associated biofluids (cell supernatants, extracellular vesicles, etc) for proteomics analysis with various quantitative approaches (e.g., label-free, SILAC, TMT) using high-resolution tandem mass spectrometry.

As part of our dynamic team, you will:

• Participate and conduct proteomics and immunopeptidomics analysis in collaboration with stakeholders in the I2S chapter and from the different therapeutic areas and functions, as needed.

• Plan and discuss the experimental strategy with the stakeholders, team members, and data scientists.

• Organize and execute proteomics experiments, including sample preparation, nano LC-MS/MS measurement using high-end mass spectrometric instrumentation, data processing and interpretation.

• Provide reports and detailed data analysis to the stakeholders in a dynamic and flexible manner.

Who you are:

You are a talented, enthusiastic and motivated individual with an extensive practical experience in the mass spectrometry-based proteomics field. You have excellent scientific, communication and organizational skills, fully committed to team effort but able to work in an independent fashion. You bring your own expertise and strategies that you are ready to apply to solve challenging and interdisciplinary project problems in an agile environment.

You own the following qualifications:

• You have a Bachelor's Degree or Master’s degree in Biological/Life Sciences, Biochemistry, or related field with 3-5 years of relevant work experience (no PhD).

• Hands-on expertise in nano liquid chromatography - mass-spectrometry based proteomics is mandatory. Experience with Orbitrap MS (Q Exactive, Exploris, and/or Tribrids) is essential, and ion mobility (timsTOF Pro, FAIMS Pro) systems is an advantage, knowledge of Bravo liquid handler is a plus

• You have hands-on experience with sample preparation for molecular biology experiments (mammalian tissue culture, protein extraction, protein assays, etc.) and with sample preparation for proteomics analysis with various quantitative approaches (e.g., label-free, SILAC, TMT).

• Proficiency with common data processing software (Proteome Discoverer, MaxQuant, Spectronaut, PEAKS) and programming (e.g. R/Python) skills are a big plus.

• You are able to keep proper experimental records, analyze, summarize and present data from your research.

• You thrive in highly collaborative environments and you have strong and interpersonal skills. You have excellent verbal and written communication skills in English.

Our commitment

• Roche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees on their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo.

• Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.